Hmg coa reductase mediated modulation of neurogenesis

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/138 (2006.01) A61K 31/4045 (2006.01) A61K 31/473 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61K 31/7056 (2006.01) A61K 45/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2664421

The instant disclosure describes methods of treating diseases and conditions of the central and peripheral nervous system including by stimulating or increasing neurogenesis, neuroproliferation, and/or neurodifferentiation. The disclosure includes compositions and methods based on use of an HMGCR modulating agent, optionally in combination with one or more other neurogenic agents, to stimulate or increase a neurogenic response and/or to treat disease.

La présente invention concerne des procédés de traitement des maladies et des affections du système nerveux central et périphérique y compris par la stimulation ou l'accroissement de la neurogenèse, de la neuro-prolifération, et/ou de la neuro-différenciation. L'invention concerne des compositions et des procédés basés sur l'utilisation d'un agent modulateur de la HMGCR, facultativement en association avec un ou plusieurs autres agents neurogènes, dans le but de stimuler ou d'augmenter une réponse neurogène et/ou de traiter une maladie.

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