Hmg coenzyme a reductase inhibitors affect the mitochondrial...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2531288

Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.

Les statines sont largement utilisées pour le traitement de niveaux de cholestérol élevés. Dans la présente invention, l'effet de statines sur l'acide nucléique mitochondrial et l'état d'activation de mitochondries est utilisé dans des méthodes permettant de déterminer si un sujet présente un risque de développer des effets indésirables liés au traitement à l'aide de statines. L'invention concerne des méthodes de traitement d'un symptôme clinique associé à une fonction mitochondriale réduite. L'invention concerne également des matériels et analogues comprenant un moyen de détection d'acide nucléique mitochondrial, ou d'activation d'une mitochondrie destinée à être utilisée dans une méthode susmentionnée.

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