C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/33, 195/45
C12P 1/00 (2006.01) C07K 14/62 (2006.01) C12M 1/12 (2006.01) C12M 1/40 (2006.01) C12N 11/08 (2006.01) C12N 11/14 (2006.01)
Patent
CA 1247541
ABSTRACT OF THE INVENTION A bioreactor comprising a hollow microsphere container and a liquid suspension or solution of biocatalyst encapsulated within the hollow microsphere. The hollow microsphere comprises a spherical porous wall comprised of sintered together inorganic particles. The microsphere wall is of substantially uniform thickness and porosity, the wall includes interconnecting voids which extend from the outer surface of the wall to the inner surface of the wall and the wall encircles an intracapsular space in the form of a single hollow central void. The intracapsular space is at least 70% filled with the biocatalyst solution or suspension. The microcapsule wall further comprises a plurality of macropore openings extending through the thickness of the wall and having a diameter larger than the major dimension of the biocatalyst, and a semipermeable membrane having a thickness substantially less than the thickness of the microsphere wall. The membrane extends across the interconnecting voids and the macropores in order to encapsulate the biocatalyst within the intracapsular space, but permitting diffusion of gases, liquids and dissolved or suspended substances having a molecular weight below a predetermined molecular weight cut-off.
492036
Borden Ladner Gervais Llp
Torobin Leonard B.
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