Hollow porous polypropylene membrane for artificial lung

Details Hollow porous polypropylene membrane for artificial lung Hollow porous polypropylene membrane for artificial lung

A - Human Necessities

61

M

18/15, 128/81.2

A61M 1/18 (2006.01) B01D 67/00 (2006.01) B01D 69/02 (2006.01) B01D 69/08 (2006.01) B01D 71/26 (2006.01) D01D 5/24 (2006.01) D01D 5/247 (2006.01)

Patent

CA 1310455

ABSTRACT OF THE DISCLOSURE A porous polypropylene hollow fiber membrane of circular cross section with a 150 to 300 µm inside diameter and a 10 to 150 µm wall thickness for use in an artificial lung. The membrane is characterized by having an inner surface aperture ratio in the range of 10 to 30%, a porosity in the range of 10 to 60%, and an oxygen flux in the range of 100 to l,000 liters/min.m2.atm. The membrane is further characterized by inducing no leakage of blood plasma within 20 hours use in the external circulation of blood therethrough. A method for the manufacture of the membrane is characterized by the steps of mixing polypropylene, an organic filler capable of uniformly dispersing in the polypropylene in a fused state and easily dissolving in an extractant being used, and a crystal seed forming agent. Discharging the resulting mixture in a molten state in the shape of a hollow fiber through an annular spinning nozzle; bringing the hollow fiber into contact with a liquid comprising the organic filler or a compound similar thereto, thereby cooling and solidifying the hollow fiber; and bridging the cooled and solidifed hollow fiber into contact with an extractant incapable of dissolving polypropylene, thereby removing the organic filler.

513615

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