Home diagnostic aid and method for determining the presence...

G - Physics – 01 – N

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150/11

G01N 33/72 (2006.01)

Patent

CA 1213197

Abstract A one-step, guaiac reagent based, diagnostic aid for determining the presence of occult blood in an aqueous system includes an absorbent carrier having absorbed thereon guaiac in a water soluble polymer matrix. A dry powdered oxidizing agent, such as a monopersulfate compound, is placed in contact with the carrier. The oxidizing agent is capable of oxidizing guaiac to a blue dye in the presence of water and hemoglobin. The oxidizing agent in the absence of water is substantially nonreactive with the guaiac in the carrier. In a second embodiment, the diagnostic aid contains a micron-sized silica gel into which a guaiac solution has been adsorbed. The guaiac-containing carrier is contacted with a dry, particulate, oxidizing agent, such as a monoper- sulfate compound, to form a single powdered reagent composition, which can, for example, be packaged in a water-pervious sandwich. When the diagnostic aid is contacted with water, the oxidizing agent is activated to produce hydrogen peroxide, which in the presence of occult blood will oxidize the guaiac to a brilliant blue reaction product.

422557

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