Homing peptides

Details Homing peptides Homing peptides

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) C07K 1/04 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 7/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2459796

A synovial tissue binding peptide comprises an amino acid sequence motif comprising RLP, SPS, HSS, LSS, TWS, YSS, NQR, DRL or DHR. Preferred motifs comprise HPRLPFA, APNWRLP, SPSPFRA, SPSRFDQ, VSPSRTT, PLSSAQR, TWSATST, THSSATQ, HTHSSNL, PNHSSPH, ADHSSRH, SDYSSRS, QTHNQRY, TNQRLAI, KSTHDRL, PFHDRHS, HPSDRLS or DRLNHQF. Also provided is a method for the identification of peptides capable of binding to a tissue originating from a first mammalian species, the method comprising the steps of: grafting the tissue originating from the first mammalian species into a subject of a second mammalian species having an attenuated immunological response; introducing a plurality of peptides into the second species; and determining the localisation of the peptides within the second species.

Cette invention concerne un peptide de liaison du tissu synovial renfermant un motif de s~quence d'acides amin~s qui comprend RLP, SPS, HSS, LSS, TWS, YSS, NQR, DRL ou DHR. Les motifs pr~f~r~s comprennent HPRLPFA, APNWRLP, SPSPFRA, SPSRFDQ, VSPSRTT, PLSSAQR, TWSATST, THSSATQ, HTHSSNL, PNHSSPH, ADHSSRH, SDYSSRS, QTHNQRY, TNQRLAI, KSTHDRL, PFHDRHS, HPSDRLS ou DRLNHQF. L'invention concerne ~galement une m~thode permettant d'identifier un peptide capable de se lier ~ un tissu provenant d'une premi­re esp­ce de mammif­re. Cette m~thode consiste ~ : greffer le tissu pr~lev~ sur une premi­re esp­ce de mammif­re sur un sujet appartenant ~ une seconde esp­ce de mammif­re qui pr~sente des r~ponses immunologiques att~nu~es; introduire une pluralit~ de peptides dans la seconde esp­ce ; et d~terminer l'emplacement des peptides dans cette seconde esp­ce.

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