A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2090317
2090317 9204053 PCTABS00011 Homoconjugated antibodies with high avidity for antigen have increased therapeutic activies and are utilized in pharmaceutical and diagnostic compositions. The homoconjugates, typically prepared from monoclonal antibodies of the IgG class which bind to the same antigenic determinant, are covalently linked by synthetic cross-linking. The homoconjugates are comprised of at least two immunoglobulin monomers so as to provide an IgG-like molecule which is tetravalent, hexavalent or more for the selected antigen. The homoconjugates are able to cross the placenta. Methods of treatment using these homoconjugates are also provided.
Raff Howard V.
Wolff Edith A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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