C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2698809
The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
L'invention concerne des procédés de production d'une augmentation de l'enrichissement et/ou de la récupération de formes préférées d'anticorps monoclonaux. L'invention concerne plus particulièrement des procédés d'élimination de l'hétérogénéité de bisulfure dans la région charnière de protéines d'anticorps recombinants IgG2.
Allen Martin J.
Balland Alain
Bondarenko Pavel
Dillon Thomas M.
Guo Amy
Amgen Inc.
Gowling Lafleur Henderson Llp
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