Homogeneous double receptor agglutination assay for...

G - Physics – 01 – N

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G01N 33/94 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2657588

A homogeneous, non-competitive, double receptor agglutination assay for measuring immunosuppressant drugs is described. The assay employs at least two receptors wherein each receptor is specific for a separate binding site on the drug and wherein each receptor is bound to a detection particle. The immunosuppressant drug binds to the receptors and causes particle agglutination, which can be measured and correlated with the presence or amount of immunosuppressant drug in a sample.

L'invention concerne un test d'agglutination homogène non compétitif sur double récepteur permettant de mesurer des médicaments immunosuppresseurs. Le test fait appel à au moins deux récepteurs, chaque récepteur étant spécifique à un site de liaison distinct sur le médicament, et chaque récepteur se liant à une particule de détection. Le médicament immunosuppresseur se lie aux récepteurs et provoque une agglutination des particules, laquelle peut être mesurée et corrélée à la présence ou à la quantité de médicament immunosuppresseur dans un échantillon.

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