C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/37 (2006.01) C07K 14/025 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2295316
The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus- like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.
La présente invention concerne des capsomères du HPV stables qui expriment au moins un épitope de conformation neutralisant le virus d'une protéine L1 native du HPV et qui sont sensiblement incapables de s'assembler en particules de type viral. Ces capsomères, en raison de leur taille plus petite et de leurs propriétés immunogènes, conviennent bien à une utilisation dans des vaccins anti-HPV et comme agents diagnostiques. De plus, en raison de leur taille plus petite (par rapport aux particules de type viral), ces capsomères stables peuvent être facilement purifiés et devraient permettre d'obtenir des vaccins anti-HPV à homogénéité accrue.
Garcea Robert L.
Mccarthy Michael P.
Rose Robert C.
Suzich Joann A.
Medimmune Inc.
Smart & Biggar
University Of Colorado University Technology Corporation
University Of Rochester
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