Homogeneous immunoassay with labeled monoclonal anti- analyte

Details Homogeneous immunoassay with labeled monoclonal anti- analyte Homogeneous immunoassay with labeled monoclonal anti- analyte

C - Chemistry, Metallurgy

12

Q

167/45

C12Q 1/00 (2006.01) C07K 16/18 (2006.01) G01N 33/542 (2006.01) G01N 33/58 (2006.01)

Patent

CA 1186622

ABSTRACT OF THE DISCLOSURE A homogeneous immunoassay method for determining an analyte, particularly analytes of molecular weight greater than about 10,000 (e.g., proteins), wherein sample is combined with a labeled monoclonal anti-analyte preparation in which the anti-analyte is substantially the only labeled component. Binding of the analyte with labeled anti-analyte results directly in a change in the detectable response gener- ated by the label, usually due to steric constraints. The method provides a simple homogeneous technique which does not require the preparation of purified analyte in order to prepare assay reagents. Alter- natively, the sample is combined with the labeled monoclonal anti-analyte and with a macromolecular conjugate having analyte epitope sites and binding of the labeled anti-analyte to such conjugate results in a change in the response of the label.

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