A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/05 (2006.01) A61K 9/48 (2006.01) A61K 9/52 (2006.01) A61K 31/135 (2006.01) A61K 31/19 (2006.01) A61K 31/34 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2216934
A controlled-release formulation comprising, in combination a therapeutically- effective dosage of drug which melts at low temperature and an additive selected from the group consisting of ethyl cellulose, methylcellulose, hydroxypropyl cellulose, polyacrylamide, ethylene vinyl acetate copolymer, polymethylmethacrylate, polyhydroxyethyl methacrylate and waxes, and the like, such that the additive and the drug form a homogeneous drug-additive composite with a 92-to-97 % weight/weight of said drug, wherein said drug is selected from the group consisting of: sodium hydrogen divalproex, ibuprofen, ramipril, dibenzyline, erythrityl tetranitrate, isosorbide dinitrate, methosuximide, ketoprofen, gemfibrozil, paroxetine hydrochloride, and trimipramine maleate.
Une formulation de substance à libération lente comprend une combinaison d'une dose thérapeutiquement efficace d'un médicament qui fond à basse température et d'un additif choisi dans le groupe comprenant éthylcellulose, méthylcellulose, hydroxypropylcellulose, polyacrylamide, un copolymère acétate de vinyle éthylène, polyméthylméthacrylate, polyhydroxyéthylméthacrylate et des cires et autres éléments semblables, de façon que l'additif et le médicament forment une substance composite homogène médicament-additif comprenant 92 à 97 % en poids de ce médicament. Ce dernier est choisi dans le groupe constitué par: sodium hydrogène divalproex, ibuprofène, ramipril, dibenzyline, érythrityle tétranitrate, isosorbide dinitrate, méthosuximide, kétoprofène, gemfibrozil, hydrochlorure de paroxétine et trimipramine maléate.
Cheskin Howard
Hale Thomas J.
Van Scoik Kurt G.
Zhou Ji
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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