Homogeneous t-4 uptake assay

Details Homogeneous t-4 uptake assay Homogeneous t-4 uptake assay

G - Physics

01

N

150/11, 150/15.2

G01N 33/78 (2006.01) C12Q 1/34 (2006.01) G01N 33/567 (2006.01) G01N 33/58 (2006.01)

Patent

CA 1317861

13 24467/MCRO-9 HOMOGENEOUS T-4 UPTAKE ASSAY ABSTRACT OF THE DISCLOSURE The present invention provides an improved assay for measuring thyroxine uptake by thyroxine bind- ing globulin in which thyroxine binding globulin (TBG) activity is measured directly. The method comprises combining a sample in an aqueous solution with an enzyme donor (ED) conjugated to an analogue of poly- iodothyronine that competes with thyroxine for thy- roxine binding globulin binding sites. An enzyme acceptor (EA) characterized by providing a modulated enzyme activity in relation to the amount of TBG activity is combined with an enzyme donor and sample in an aqueous solution. The amount of enzyme activity in comparison to a control solution having a known amount of available TBG binding sites is determined.

579043

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