Homogenotization of gene-targeting events

Details Homogenotization of gene-targeting events Homogenotization of gene-targeting events

C - Chemistry, Metallurgy

12

N

C12N 15/90 (2006.01) C12N 5/10 (2006.01) C12N 15/65 (2006.01) C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2128862

Homozygotic cells are obtained by employing homologous recombination with a construct comprising a marker gene. The marker gene allows for selection without amplification and by employing elevated levels of the antibiotic to which the marker gene imparts resistance, gene conversion can occur, where in a diploid host, both copies of the target locus will be the same. In this manner, knock-outs of genes can be readily achieved without requiring two steps of homologous recombination.

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