G - Physics – 01 – N
Patent
G - Physics
01
N
150/3, 167/37, 1
G01N 33/48 (2006.01) C07D 209/48 (2006.01) C07D 237/32 (2006.01) C07D 493/10 (2006.01) C07D 495/04 (2006.01) C07H 21/00 (2006.01) C12Q 1/28 (2006.01) G01N 33/533 (2006.01)
Patent
CA 1082577
ABSTRACT OE OF DISCLOSURE A test composition, device, and method for their use in a homogenous specific binding assay which employs a sub- stance having reactant activity, i.e., a reactant, as a labeling substance in the detection of a ligand in a liquid medium The test composition and device comprise a conju- gate formed of a specific binding substance coupled to the reactant. The reactant advantageously is an enzymatic reactant such as an enzyme substrate or coenzyme. The activity of the conjugated reactant as a constituent of a predetermined reaction is affected by reaction between the specific binding substance in the conjugate and a specific binding counterpart thereto. The presence of a ligand in a liquid medium may be determined using competitive or displace- ment binding or sequential saturation techniques wherein the specific binding substance in the conjugate is the ligand or a specific binding analog thereof, or using a direct binding technique wherein the specific binding substance is a specific binding partner of the ligand. The effect of the specific binding reaction on the activity of the conjugated reactant is related to the presence or amount of the ligand in the liquid medium tested.
249745
Boguslaski Robert C.
Carrico Robert J.
Christner James E.
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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