C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61P 31/04 (2006.01) C07K 14/29 (2006.01) C07K 16/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2352466
The present invention is directed to the cloning, sequencing and expression of homologous immnunoreactive 28-kDa protein genes, ECa28-1 and ECa28SA3, from a polymorphic multiple gene family of Ehrlichia canis. A complete sequence of another 28-kDa protein gene, ECaSA2, is also provided. Further disclosed is a multigene locus encoding all five homologous 28-kDa protein genes of Ehrlichia canis. Recombinant Ehrlichia canis 28-kDa proteins react with convalescent phase antiserum from an E. canis-infected dog.
La présente invention concerne le clonage, le séquençage et l'expression de gènes protéiques homologues immunoréactifs de 28 kDa (ECa28-1 et ECa28SA3) appartenant à une famille génique multiple polymorphe de Ehrlichia canis. Elle concerne également une séquence complète d'un autre gène protéique de 28 kDa (EcaSA2). L'invention concerne en outre un locus multigène codant tous les cinq gènes protéiques homologues de 28 kDa de Ehrlichia canis. Des protéines recombinantes de 28 kDa de Ehrlichia canis réagissent en présence d'un antisérum de phase convalescente obtenu chez un chien infecté par E. canis.
Mcbride Jere W.
Walker David H.
Yu Xue-Jie
Borden Ladner Gervais Llp
Research Development Foundation
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