Homologous amds genes as selectable marker

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 9/80 (2006.01)

Patent

CA 2583460

The present invention relates to novel functional amdS genes from A.niger that can be used as dominant and bi-directional selection marker gene in the transformation of organisms. The present invention further relates to the production of a compound of interest in a fungal host cell transformed with the amdS genes of the invention. Preferred fungal host cells are filamentous fungal cells. The amdS genes of the invention provide means for identification of functional homologues in other Aspergillus species.

Cette invention concerne de nouveaux gènes fonctionnels amdS d'A.niger qui peuvent être utilisés comme gène marqueur de sélection, dominant et bidirectionnel, dans la transformation d'organismes. Cette invention concerne également la production d'un composé d'intérêt dans une cellule hôte fongique transformée à l'aide des gènes amdS décrits dans l'invention. Les cellules hôtes fongiques préférées sont des cellules fongiques filamenteuses. Les gènes amdS tels que décrits dans l'invention servent de moyens d'identification d'homologues fonctionnels présents dans d'autres espèces du genre Aspergillus.

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