Homologous recombination for animal model exhibiting reduced...

Details Homologous recombination for animal model exhibiting reduced... Homologous recombination for animal model exhibiting reduced...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2210520

Transgenic non-human mammals and methods of preparing such mammals are disclosed. Homologous recombination is employed to inactivate genes, particularly genes coding for neuronal intermediate filaments. These animals, whose phenotypeis characterized by reduced or eliminated levels of a neuronal intermediate filament, are useful as models for studying aging, injury to the nervous system, and pathogenesis of neurodegenerative diseases. They are also useful for the screening of potential therapeutic agents.

Mammifères transgéniques non humains et méthode pour les créer. La recombinaison homologue est employée pour inactiver les gènes, notamment les gènes codant les filaments neuronaux intermédiaires. Ces animaux, dont le phénotype est caractérisé par des taux réduits ou nuls de filaments neuronaux intermédiaires, sont utiles comme modèles pour étudier l'âge, les lésions du système nerveux et la pathogenèse des maladies neurodégénératives. Ils sont utiles aussi pour dépister d'éventuels agents thérapeutiques.

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