Homologous recombination for universal donor cells and...

Details Homologous recombination for universal donor cells and... Homologous recombination for universal donor cells and...

C - Chemistry, Metallurgy

12

N

167/104, 195/1.1

C12N 15/85 (2006.01) A61K 35/12 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2037907

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. particularly, the .beta.2-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts.

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