Homologs of a pneumococcal protein and fragments for vaccines

Details Homologs of a pneumococcal protein and fragments for vaccines Homologs of a pneumococcal protein and fragments for vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/09 (2006.01) A61K 39/40 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2382795

The invention is directed to isolated polypeptides bearing sequence homology to the Sp36 protein found in pneumococcal organisms, such as Streptococcus pneumoniae. Polynucleotides encoding such polypeptides are also disclosed. The invention also relates to antibodies specific for the disclosed polypeptides and to uses of such antibodies in the treatment of diseases caused by staphylococci as well as group A and B streptococci. In addition, the invention relates to the use of the disclosed polypeptides in compositions and as vaccines and for prophylactic uses such as in vaccination of animals, especially humans, against a wide variety of streptococcal, staphylococcal and other diseases.

La présente invention concerne des polypeptides isolés présentant une homologie de séquence avec la protéine Sp36 trouvée dans des organismes pneumococciques tels que Streptococcus pneumoniae . L'invention concerne également des polynucléotides codant de tels polypeptides. L'invention concerne aussi des anticorps spécifiques des polypeptides de l'invention et l'utilisation de tels anticorps pour le traitement d'affections imputables aux staphylocoques ainsi qu'aux streptocoques des groupes A et B. L'invention concerne enfin l'utilisation des polypeptides de l'invention dans des compositions et en tant que vaccins, ainsi que leur utilisation prophylactique notamment pour la vaccination d'animaux, spécialement des humains, contre une grande variété d'affections à streptocoques, à staphylocoques et autres.

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