C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) G01N 33/566 (2006.01) G01N 33/94 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2378151
The present invention provides cell lines expressing a recombinant heteromeric AMPA glutamate receptor, preferably a human heteromeric AMPA glutamate receptor, or a recombinant human homomeric AMPA glutamate receptor. The invention also provides methods for preparing said cell lines. The invention furthermore pertains to the use of said cell lines for the identification of glutamate receptor agonists, antagonists or modulators and methods for the identification of said agonists, antagonists or modulators. The invention also provides pharmaceutical compositions comprising said agonists, antagonists or modulators. The invention furthermore is concerned with the use of agonists, antagonists or modulators in the manufacture of a medicament for the treatment of neurological disorders.
L'invention concerne des lignées cellulaires exprimant un récepteur AMPA hétéromère recombiné du glutamate, de préférence un tel récepteur humain, ou un récepteur AMPA homomère humain recombiné du glutamate. L'invention concerne également des procédés de préparation de telles lignées cellulaires, ainsi que l'utilisation de ces lignées dans l'identification d'agonistes, antagonistes ou modulateurs du récepteur du glutamate. Elle concerne encore des procédés d'identification de ces agonistes, antagonistes ou modulateurs, de même que des compositions pharmaceutiques contenant ces agonistes, antagonistes ou modulateurs, ainsi que l'utilisation de ceux-ci dans la fabrication d'un médicament destiné au traitement de troubles neurologiques.
Akiba Isamu
Barsoumian Edward Leon
Iizuka Masaki
Nishimura Seiichiro
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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