Homopropargylamines

Details Homopropargylamines Homopropargylamines

C - Chemistry, Metallurgy

07

C

167/179, 167/23.

C07C 211/31 (2006.01) A01N 33/04 (2006.01) A61K 31/13 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/695 (2006.01) C07D 307/82 (2006.01) C07D 333/52 (2006.01)

Patent

CA 1276027

NOVEL HOMOPROPARGYLAMINES Abstract of the Disclosure The invention relates to novel homopropargylamines of formula I Image I wherein n is 2 or 3, R1 is a group of formula IIa, IIb or IIc Image IIa IIb IIc in which R6 and R7 independently are H, halogen, CF3, lower alkyl or lower alkoxy, s is a number of 3 to 5, X is 0, S, OCH2, SCH2, CH2 or NR8, and R8 is H or lower alkyl, R2 is H or lower alkyl, either R3 and R4, independently, are H or lower alkyl, or R3 and R4 together are (CH2)u, in which u is a number of 3 to 5, and R5 is H, alkenyl or is a group selected from alkyl, trialkylsilyl, dialkylphenylsilyl. phenyl, phenylalkyl and cyclcloalkyl in which alkyl, phenyl and cycloalkyl groups or moieties are unsubstituted or substituted by OH, lower alkyl, lower alkoxy, phenyl or halogen, in free base form or acid addition salt form thereof, their preparation, their chemotherapeutical and agricultural use and to compositions comprising such novel compounds and suitable for such use.

495876

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