A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/05 (2006.01) A61K 9/00 (2006.01) A61P 35/00 (2006.01) C07C 39/21 (2006.01)
Patent
CA 2753209
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are honokiol analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers. Representative honokiol analogs include diepoxide honokiol analogues. The compounds are believed to function, at least, by inhibiting angiogenesis and/or inducing apoptosis. Thus, the compounds are novel therapeutic agents for a variety of cancers.
L'invention concerne des composés, des compositions pharmaceutiques contenant ces composés, et des procédés de préparation et d'utilisation de ceux-ci. Ces composés consistent en des analogues d'honokiol. Ces composés et ces compositions peuvent être utilisées dans le traitement et/ou la prévention d'une grande variété de cancers, y compris les cancers résistant aux médicaments. Les analogues d'honokiol représentatifs contiennent des analogues d'honokiol diépoxyde. Ces composés semblent fonctionner par inhibition de l'angiogenèse et/ou par induction de l'apoptose. Ainsi, les composés de l'invention consistent en de nouveaux agents thérapeutiques d'une variété de cancers.
Arbiser Jack L.
Arbiser Jack L.
Ridout & Maybee Llp
LandOfFree
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