Hormone-mediated methods for modulating expression of...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 31/56 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/72 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2251466

In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing same, nucleic acids encoding invention modified ecdysone receptors, modified ecdysone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.

Cette invention a trait à diverses techniques de modulation de l'expression d'un gène exogène chez un mammifère par l'emploi de récepteurs d'ecdysone modifiée. Elle a également trait à des récepteurs d'ecdysone modifiée ainsi qu'à des récepteurs homomères et hétérodimères la contenant, à des acides nucléiques codant les récepteurs d'ecdysone modifiée selon l'invention, à des éléments de réponse d'ecdysone modifiée, à des vecteurs de transfert génique, à des cellules de recombinaison et à des animaux transgéniques porteurs d'acides nucléiques codant le récepteur d'ecdysone modifiée selon l'invention.

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