Host cell lines for production of antibody constant region...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/16 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2621236

Host cell lines for biopharmaceutical production of antibodies, antibody fragments or antibody-derived fusion proteins are selected as having the capability of inducing improved cellular effector functions, e.g., Fc- medicated effector functions. The host cells are derived from the rat myeloma cell line YB2/0 and are adapted to growth in chemically-defined medium.

L'invention porte sur des lignées cellulaires hôtes destinées à la production biopharmaceutique d'anticorps, de fragments d'anticorps ou de protéines de fusion dérivées des anticorps, ces lignées cellulaires étant sélectionnées pour avoir la capacité d'induire de meilleures fonctions effectrices cellulaires, telles que des fonctions effectrices induites par Fc. Les cellules hôtes sont dérivées de la lignée cellulaire myélomateuse du rat, YB2/0, et sont adaptées pour proliférer dans un milieu défini chimiquement.

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