C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/75 (2006.01) C12N 9/02 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2719559
The invention provides for genetically modified Bacillus host cells having decreased cytoplasmic reductase activity, such as decreased TrxA activity, and a nucleic acid encoding a heterologous Staphylococcal oxidase. The invention also provides for methods of producing di-sulfide bond containing proteins using the host cells of the invention and methods of improving protein folding using the host cell of the invention.
La présente invention concerne des cellules hôtes de Bacillus génétiquement modifiées présentant une activité de réductase cytoplasmique réduite, telle quune activité TrxA réduite, et un acide nucléique codant pour une expression hétérologue doxydase staphylococcale. Linvention concerne également des procédés de production de protéines contenant des liaison disulfure mettant en uvre les cellules hôtes selon linvention et des procédés damélioration de repliement de protéines mettant en uvre les cellules hôtes selon linvention.
Dubois Jean-Yves Francois
Kouwen Roelof Hendrik Matthijs
Van Dijl Jan Maarten
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Danisco Us Inc.
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