Host cells having improved cell survival properties and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/10 (2006.01) C07K 14/47 (2006.01) C12N 5/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2480684

The present invention relates to genetically engineered mammalian host cells comprising an enhanced level of active anti-apoptosis genes and methods to generate such host cells. More particularly, the invention pertains to methods which modulate the level of anti-apoptosis active genes within host cells and to host cells showing an enhanced cell viability by delaying/inhibiting programmed cell death naturally occurring in such cells. The present invention also provides new anti-apoptosis genes suitable fro the preparing host cells showing an enhanced cell viability by delaying/inhibiting programmed cell death naturally occurring in such cells.

La présente invention concerne des cellules hôtes de mammifère produites par génie génétique, qui présentent un taux supérieur de gènes anti-apoptoses actifs, ainsi que des procédés de production de telles cellules hôtes. Plus particulièrement, l'invention concerne des procédés permettant de moduler le taux de gènes anti-apoptoses actifs à l'intérieur desdites cellules hôtes, ainsi que des cellules hôtes présentant une viabilité cellulaire améliorée, cela grâce au retardement/à l'inhibition de la mort cellulaire programmée se produisant naturellement avec de telles cellules. La présente invention concerne aussi de nouveaux gènes anti-apoptoses pouvant être utilisés pour l'obtention de cellules hôtes présentant une viabilité cellulaire améliorée, obtenues grâce au retardement/à l'inhibition de la mort cellulaire programmée se produisant naturellement avec de telles cellules.

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