A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 39/29 (2006.01) A61L 2/00 (2006.01) C07K 1/22 (2006.01) C07K 14/18 (2006.01) C12N 7/00 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2305715
The finding that the human proteins annexin V, tubulin and apolipoprotein B bind to the hepatitis C virus envelope proteins E1 and/or E2 and the usage of these human proteins to diagnose and treat an infection with hepatitis C virus are described. The usage of the latter proteins to enrich HCV envelope proteins and molecules which inhibit binding of HCV to these human proteins, as well as vaccines employing the E1 and/or E2 binding domains are also disclosed.
L'invention se rapporte au fait que les protéines humaines que sont l'annexine V, la tubuline et l'apolipoprotéine B se lient aux protéines E1 et/ou E2 de l'enveloppe du virus de l'hépatite C (VHC), et à l'utilisation de ces protéines humaines pour diagnostiquer et traiter une infection par le virus de l'hépatite C. L'invention concerne également l'utilisation de ces protéines pour enrichir les protéines de l'enveloppe du VHC et les molécules qui inhibent la liaison du VHC à ces protéines humaines, ainsi que les vaccins qui font usage des domaines de liaison aux protéines E1 et/ou E2.
Depla Erik
Maertens Geert
Innogenetics N.v.
Smart & Biggar
LandOfFree
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