House dust mite allergen

Details House dust mite allergen House dust mite allergen

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2646158

A polypeptide comprising an amino acid sequence having at least 60 % identity to the amino acid sequence SEQ ID No. 1 or comprising at least one amino acid fragment of at least 6 consecutive amino acid residues of the amino acid sequence SEQ ID No. 1 or having immunological cross-reactivity to the amino acid sequence SEQ ID No. 1 or fragments thereof, wherein the amino acid sequence SEQ ID No. 1 codes for an allergen and the polypeptide comprises at least one T cell epitope recognized by a T cell receptor specific for a molecule having the amino acid sequence SEQ ID No. 1.

L'invention concerne un polypeptide comprenant une séquence d'acides aminés ayant au moins 60 % d'identité avec la séquence d'acides aminés SEQ. ID No. 1 ou comprenant au moins un fragment d'acides aminés d'au moins six restes d'acides aminés consécutifs de la séquence d'acides aminés SEQ. ID No. 1 ou ayant une réactivité croisée immunologique avec la séquence d'acides aminés SEQ. ID No. 1 ou des fragments de celle-ci, la séquence d'acides aminés SEQ. ID No. 1 codant pour un allergène et le polypeptide comprenant au moins un épitope de lymphocyte T reconnu par un récepteur de lymphocyte T spécifique pour une molécule ayant la séquence d'acides aminés SEQ. ID No. 1.

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