Hp-8 autoantigen

Details Hp-8 autoantigen Hp-8 autoantigen

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2230627

An autoantigen identified as HP-8 which is related to systemic lupus erythematosus. The HP-8 antigen is expressed by a gene which was identified by immunoscreening of human placental cDNA GT11 expression library with the monoclonal antibody 3E10. The 3E10 antibody is a low-affinity anti-double-stranded DNA autoantibody derived from the MRL murine models for human systemic lupus erithematosus..

Un autoantigène nommé HP-8 qui est lié au lupus érythémateux disséminé. L'antigène HP-8 est exprimé par un gène qui a été détecté par immunocriblage de la banque d'expression d'ADNc placentaire humain GT11 avec l'anticorps monoclonal 3E10. L'anticorps 3E10 est un autoanticorps de faible affinité anti-ADN double-brin dérivé des modèles murins MRL du lupus érythémateux disséminé humain.

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