Hprp4s as modifiers of the p53 pathway and methods of use

Details Hprp4s as modifiers of the p53 pathway and methods of use Hprp4s as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C12Q 1/02 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2454519

Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.

L'invention concerne des gènes humains hPRP4 qui sont identifiés comme des modulateurs de la voie de passage p53 et qui sont, donc, des cibles thérapeutiques destinées à des troubles liés à la fonction de p53 déficiente. Cette invention a également trait à des méthodes d'identification des modulateurs de p53 consistant à cribler des agents qui modulent l'activité de hPRP4.

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