C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/635 (2006.01) A61K 38/29 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2071538
The invention relates to a peptide from human blood, designated as hPTH-(1- 37), the structure of which was elucidated for the purpose of the diagnostic, medical and commercial utilization thereof. The isolation of a fragment hPTH-(38-84) proves the existence of the hPTH-(1-37). A removal of amino-terminal amino acids from the hPTH fragment-(1-37) reduces its biological activity. The hPTH-(1-37) circulating in the blood is identical with the synthetic reference substance hPTH-(1-37), however not with fragments such as hPTH-(1-33), hPTH-(1-34) or hPTH-(1-38). The molecule form hPTH-(1-37) has been proven by mass spectrometry (plasma desorption method). A different biological activity and differences in the three-dimensional peptide structure of the hPTH fragment-(1-37) in comparison to other hPTH fragments furnish evidence of that this fragment is the preferential natural peptide of the parathormone family which should be used for the treatment of diseases of the parathyroid, circulatory system, respiratory system, male genital organ and kidneys.
Adermann Knut
Forssmann Wolf-Georg
Gagelmann Michael
Herbst Franz
Schulz-Knappe Peter
Forssmann Wolf-Georg
Haemopep Pharma Gmbh
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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