A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/025 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2406485
The invention provides oligonucleotides capable of inhibiting human papillomavirus (HPV) replication. More specifically, the invention provides oligonucleotides complementary to the translational start site of the HPV E1 open reading frame which inhibit HPV replication through interaction with a nucleic acid or a protein target. Oligonucleotides of the invention contain at least 4 deoxyribonucleotides and/or ribonucleotides and may include a variety of modifications to the internucleotide linkages or the mononucleotides. Furthermore, the invention provides pharmaceutical compositions and methods for treating disorders or diseases associated with HPV infection.
La présente invention concerne des oligonucléotides capables d'inhiber la réplication du papillomavirus (HPV). Cette invention concerne plus spécifiquement des oligonucléotides complémentaires au site de départ de traduction de la phase de lecture ouverte du HPV E1 qui inhibe la réplication du HPV par interaction avec un acide nucléique ou avec une cible protéinique. Les oligonucléotides de cette invention contiennent au moins 4 désoxyribonucléotides et/ou ribonucléotides et peuvent inclure diverses modifications des liaisons internucléotidiques ou des mononucléotides. Cette invention concerne aussi des compositions pharmaceutiques et des techniques de traitement des pathologies ou des maladies associées à l'infection par le HPV.
Iyer Radhakrishnan
Jin Yi
Roland Arlene
Zhou Wenqiang
Gowling Lafleur Henderson Llp
Micrologix Biotech Inc.
Origenix Technologies Inc.
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