Hpv vaccine comprising peptides from host cell proteins

Details Hpv vaccine comprising peptides from host cell proteins Hpv vaccine comprising peptides from host cell proteins

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2575610

The present invention relates to a human papillomavirus (HPV) vaccine that comprises peptides from host cell proteins and more particularly, a vaccine that is directed against cancers that are associated with HPV infections, such as cervical cancer, head and neck cancer and skin cancers. The peptides comprise fragments of host cell proteins that have been targeted for degradation by HPV proteins, such as E6 and E7 and are presented on the surface of HPV infected cells in relatively large amounts. These peptides can be recognised by CTL and elicit an immune response, and are therefore ideal tumour-specific markers. The invention also relates to novel peptide: peptide complexes such as peptide/HLA complexes and their use in a tumour-specific vaccine.

L'invention concerne un vaccin pour le papillomavirus humain (HPV). Ce vaccin comprend des peptides provenant de protéines cellulaires hôtes. L'invention concerne en particulier un vaccin qui est dirigé contre les cancers associés à des infections HPV, notamment le cancer cervical, le cancer de la tête et du cou, et les cancers de la peau. Les peptides de l'invention comprennent des fragments de protéines de cellules hôtes qui ont été ciblées pour une dégradation par les protéines HPV, notamment E6 et E7, et sont présentés, en quantités relativement grandes, sur la surface de cellules infectées par HPV. Ces peptides peuvent être reconnus par CTL et peuvent éliciter une réponse immunitaire, ils constituent par conséquent des marqueurs idéaux spécifiques à une tumeur. L'invention concerne un nouveau peptide: des complexes de peptides notamment des complexes peptide/HLA, et leur utilisation dans un vaccin spécifique à une tumeur.

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