Hsp therapy in conjunction with a low antigenicity diet

Details Hsp therapy in conjunction with a low antigenicity diet Hsp therapy in conjunction with a low antigenicity diet

A - Human Necessities

61

K

A61K 38/17 (2006.01) A23L 1/305 (2006.01) A61K 38/10 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2595520

The present invention fragments and analogs of heat shock proteins in combination with a low antigenicity diet for suppression, prevention and treatment of diabetes. The invention is exemplified using DiaPep277TM , an analog of residues 437-460 of human Hsp60 in combination with a hydrolyzed casein diet. The invention further relates to orally active pharmaceutical compositions comprising Hsp60 fragments and analogs, such as DiaPep277, useful for suppression, prevention or treatment of diabetes and to a regimen for delaying the onset of type 1 diabetes and for inhibition of insulitis.

L'invention concerne des fragments et des analogues de protéines du stress, combinés à un régime à faible antigénicité, pour supprimer, pour prévenir et pour traiter des diabètes. Un mode de réalisation d'exemple de l'invention fait appel à DiaPep277<SP>TM</SP>, un analogue de résidus de 437-460 de Hsp60 humain combiné à un régime de caséine hydrolysée. L'invention concerne également des compositions pharmaceutiques oralement actives comprenant des fragments et des analogues de Hsp60, notamment de DiaPep277, utiles pour supprimer, pour prévenir ou pour traiter des diabètes et pour un schéma posologique permettant de retarder le déclenchement de diabètes de type 1 et d'inhiber une insulite.

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