C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2483556
The invention relates to specific peptides derived from hsp70, and to pharmaceutical compositions comprising the same. The peptides and compositions of the invention are particularly suitable for the prevention or treatment of an autoimmune disease such as Type 1 Diabetes, Systemic Lupus Erithematosus, Multiple Sclerosis or Rheumatoid Arthritis. The invention further relates to a method for diagnosing the occurrence or incipience of an autoimmune disease in a patient by use of the peptides of the invention, by testing a blood or urine sample of a patient for the presence of antibodies or T-cells which are immunologically reactive to human hsp70.The invention also relates to a kit for the diagnosis of an autoimmune disease by testing for the presence of anti- hsp70 antibodies by aid of the peptides of the invention.
L'invention concerne des peptides spécifiques dérivés de hsp70, et des compositions pharmaceutiques les contenant. Ces peptides et ces compositions de l'invention conviennent particulièrement à la prévention et au traitement de maladies auto-immunes, telles que le diabète type 1, le lupus érythémateux systémique, la sclérose en plaques ou la polyarthrite rhumatoïde. L'invention concerne également un procédé destiné à diagnostiquer la survenue ou l'apparition d'une maladie auto-immune chez un patient par utilisation de peptides de l'invention, par analyse d'un échantillon de sang ou d'urine d'un patient afin de déceler la présence d'anticorps ou de lymphocytes T immunologiquement réactifs au hsp70 humain. L'invention concerne enfin un nécessaire destiné à diagnostiquer une maladie auto-immune par analyse à l'aide de peptides de l'invention afin de déceler la présence d'anticorps anti-hsp70.
Abulafia-Lapid Rivka
Atlan Henri
Cohen Irun R.
Hadasit Medical Research Services & Development Ltd.
Ridout & Maybee Llp
Yeda Research & Development Co. Ltd.
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