Hst-2 mutein, dna coding for the same and preparation thereof

Details Hst-2 mutein, dna coding for the same and preparation thereof Hst-2 mutein, dna coding for the same and preparation thereof

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2115522

hst-2 MUTEIN, DNA CODING FOR THE SAME AND PREPARATION THEREOF Abstract of Disclosure The present invention provides a polypeptide represented by the following amino acid sequence: (Met)n X Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu Gln Val Leu Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val Ser Leu Phe Gly Val Arg Ser Ala Leu Phe Val Ala Met Asn Ser Lys Gly Arg Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr Gln Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile wherein n is 0 or 1 and X represents Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly or a fragment thereof (n=0: SEQ ID NO:1, n=1: SEQ ID NO:2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant. The invention also provides a method for promoting an increase in the number of platelets in a mammal using a polypeptide having a heparin binding secretory transforming factor 2 (hst-2) activity. The polypeptide can be produced in large amounts, and has hst-2 activity, so that it can be advantageously used as drugs for promoting treatment of burns, wounds, etc., and therapeutic agents for gastrointestinal ulcers. Further, it can be utilized as platelet-increasing agents.

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