Hsv-2 type-specific immunoassays using glycoprotein g2 peptides

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/70 (2006.01)

Patent

CA 2558246

The present invention relates to peptides that are derived from HSV-2 glycoprotein G2 and represent HSV-2 type-specific epitopes. The present invention also provides for compositions comprising these peptides for type- specific serological diagnosis of HSV-2 infection. Methods of using these peptides for type-specific detection of HSV-2 antibodies and differentiation of HSV-2 viral infection from HSV-1 and other herpes family viral infections are further provided.

La présente invention concerne des peptides dérivés de la glycoprotéine G2 du VHS-2, qui représentent des épitopes spécifiques du VHS de type 2. L'invention concerne également des compositions contenant ces peptides, destinées au diagnostic sérologique d'une infection spécifique du VHS de type 2. L'invention concerne en outre des méthodes d'utilisation desdits peptides pour détecter des anticorps spécifiques du VHS de type 2 et différencier une infection virale à VHS-2 issue de VHS-1 et d'autres infections virales de la famille herpétique.

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