C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) C07H 21/00 (2006.01) C07K 5/103 (2006.01) C07K 7/08 (2006.01) C07K 14/035 (2006.01) C07K 16/40 (2006.01) C12N 9/50 (2006.01) C12N 15/38 (2006.01) C12Q 1/70 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2169748
Essentially pure HSV-2 UL26 gene products and fragments thereof including mature HSV-2 protease and active fragments thereof are disclosed. Essentially pure HSV-2 UL26.5 gene products and fragments thereof including mature HSV-2 capsid protein and functional fragments are disclosed. Isolated nucleic acid molecules comprising all or part of the HSV-2 UL26 gene and/or the HSV-2 UL26.5 gene are disclosed. Expression vectors and host cells comprising such nucleic acid molecules are disclosed. Methods of identifying compounds that inhibit HSV-2 protease activity and methods of identifying compounds that inhibit HSV-2 virion assembly are disclosed. Synthetic HSV-2 substrates are disclosed. Antibodies that selectively bind to HSV-2 protease processed substrates but not unprocessed substrates or unprocessed substrates but not processed substrates are disclosed. Methods of and kits for distinguishing between HSV-1 DNA or protein and HSV-2 DNA or protein and reagents useful in such methods and kits are disclosed.
L'invention porte sur des produits géniques pratiquement purs dits HSV-2 UL26 et ses fragments parmi lesquels la protéase mature HSV-2 et ses fragments actifs, sur des produits géniques pratiquement purs dits HSV-2 UL26.5 et ses fragments parmi lesquels la protéine capside HSV-2 et ses fragments fonctionnels, sur des molécules d'acide nucléique comprenant tout ou partie des gènes HSV-2 UL26 et/ou HSV-2 UL26.5, sur des vecteurs d'expression et des cellules hôtes comprenant les acides nucléiques et les molécules susdits, sur des méthodes d'identification des composés inhibant l'activité de la protéase HSV-2 et sur des méthodes d'identification des composés inhibant les ensembles de virions du HSV-2, sur des substrats de synthèse du HSV-2, sur des anticorps se fixant sélectivement aux substrats traités par la protéase du HSV-2 mais pas aux substrats non traités ou alors à des substrats non traités et pas à des substrats traités , g) sur des méthodes et trousses permettant de distinguer l'ADN ou les protéines HSV-1, de l'ADN et les protéines HSV-2 ainsi que les réactifs associés.
Debouck Christine Marie
Dilella Anthony G.
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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