Htk ligand

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/71 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2194955

A novel hepatoma transmembrane kinase receptor ligand (Htk ligand) which binds to, and activates, the Htk receptor is disclosed. As examples, mouse and human Htk ligands have been identified in a variety of tissues using a soluble Htk- Fc fusion protein. The ligands have been cloned and sequenced. The invention also relates to nucleic acids encoding the ligand, methods for production and use of the ligand, and antibodies directed thereto.

L'invention se rapporte à un nouveau ligand du récepteur de la kinase transmembranaire d'un hépatome (ligand de Htk) qui se fixe au récepteur de Htk et l'active. Par exemple, des ligands de Htk de la souris et de l'homme ont été identifiés dans une variété de tissus à l'aide d'une protéine de fusion de Htk-Fc soluble. Les ligands ont été clonés et séquencés. L'invention se rapporte également aux acides nucléiques codant le ligand, aux procédés de production et d'utilisation du ligand et aux anticorps dirigés contre celui-ci.

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