Htlv-i and htlv-ii peptide antigens and methods

Details Htlv-i and htlv-ii peptide antigens and methods Htlv-i and htlv-ii peptide antigens and methods

C - Chemistry, Metallurgy

07

K

C07K 14/15 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) C07K 4/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2100586

Novel HTLV-I and HTLV-II peptide antigens are disclosed for use in diagnostics assays for screening and confirming HTLV-I and HTLV-II antisera. The peptides are derived from analogous regions of HTLV-I and HTLV-II gp 46 envelope proteins; and are differentiated by their immunoreactivity with an HTLV-II specific monoclonal antibody and by HTLY-I and HTLY-II antisera. The peptides are also useful in-vaccine compositions.

L'invention se rapporte à de nouveaux antigènes de peptides de HTLV-I et HTLV-II s'utilisant dans des analyses diagnostiques servant à évaluer et à confirmer les antisérums de HTLV-I et HTLV-II. Les peptides sont dérivés de régions analogues de protéines enveloppantes de HTLV-I et HTLV-II gp 46 et sont différenciés par leur immunoréactivité à un anticorps monoclonal spécifique de HTLV-I et par leurs antisérums de HTLV-I et HTLV-II. Lesdits peptides sont également efficaces dans des compositions de vaccins.

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