Hu-b1.219, a novel human hematopoietin receptor

Details Hu-b1.219, a novel human hematopoietin receptor Hu-b1.219, a novel human hematopoietin receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176463

The present invention relates to a novel member of the hematopoietin receptor family, herein referred to as Hu-B1.219. In particular, the invention relates to nucleotide sequences and expression vectors encoding Hu-B1.219 gene product. Genetically engineered host cells that express the Hu-B1.219 coding sequence may be used to evaluate and screen for ligands or drugs involved in Hu-B1.219 interaction and regulation. Since Hu-B1.219 expression has been detected in certain human fetal tissues and cancer cells, molecular probes designed from its nucleotide sequence may be useful for prenatal testing and cancer diagnosis.

La présente invention concerne un nouveau membre de la famile des récepteurs de l'hématopoïétine, dénommé, en l'occurrence, Hu-B1.219, ainsi que des séquences nucléotidiques et des vecteurs d'expression codant pour le produit génique du Hu-B1.219. On peut utiliser des cellules hôtes obtenues par génie génétique, lesquelles expriment la séquence codant Hu-B1.219, pour évaluer et cribler des ligands ou des substances intervenant dans des interactions du Hu-B1.219 et sa régulation. Dans la mesure où l'expression du Hu-B1.219 a été détectée dans certains tissus foetaux et cellules cancéreuses chez l'homme, des sondes moléculaires conçues à partir de sa séquence nucléotidique peuvent se révéler utiles, dans des tests prénataux et le diagnostic du cancer.

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