Human abc2 transporter and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2383063

The invention provides isolated nucleic acid molecules, designated ABC2 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABC2 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ABC2 transporter gene has been introduced or disrupted. The invention still further provides isolated ABC2 transporter proteins, fusion proteins, antigenic peptides, anti-ABC2 transporter antibodies, and screening assays for ABC2 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules isolées d'acide nucléique, dénommées molécules d'acide nucléique de transport des ABC2, codant les nouveaux membres de la famille des transporteurs ABC. L'invention concerne également des molécules d'acide nucléique anti-sens, des vecteurs d'expression de recombinaison contenant des molécules d'acide nucléique de transport des ABC2, des cellules hôtes dans lesquelles des vecteurs d'expression ont été introduits, et des animaux transgéniques non humains dans lesquels un gène transporteur ABC2 a été introduit ou perturbé. L'invention porte, en outre, sur des protéines de transport ABC2, des protéines de fusion, des peptides antigéniques, des anticorps de transport anti-ABC2, et des méthodes de criblage pour les modulateurs de transport ABC2. L'invention concerne enfin, des procédés diagnostiques et thérapeutiques utilisant des compositions de la présente invention.

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