Human adam-10 inhibitors

Details Human adam-10 inhibitors Human adam-10 inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/19 (2006.01) A61K 31/16 (2006.01) A61K 31/44 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07C 259/06 (2006.01) C07C 259/08 (2006.01) C07C 311/29 (2006.01) C07D 207/09 (2006.01) C07D 211/34 (2006.01) C07D 213/32 (2006.01) C07D 213/56 (2006.01) C07D 213/65 (2006.01) C07D 213/68 (2006.01) C07D 213/70 (2006.01) C07D 233/48 (2006.01) C07D 233/54 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 295/185 (2006.01) C07D 295/215 (2006.01) C07D 311/70 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2473938

The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM- 10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.

La présente invention concerne des composés convenant à l'inhibition de la protéine ADAM-10. De tels composés conviennent particulièrement pour l'étude in-vitro du rôle de l'ADAM-10 (et de son inhibition) dans des processus biologiques. L'invention concerne également des compositions pharmaceutiques comprenant au moins un inhibiteur de l'ADAM-10 de l'invention en association avec un vecteur pharmaceutiquement admis. De telles compositions conviennent particulièrement pour le traitement du cancer de l'arthrite, et d'affections en lien avec l'angiogenèse. De la même façon, l'invention concerne des procédés convenant au traitement de formes de cancer, de l'arthrite, et d'affections en lien avec l'angiogenèse dans lesquelles l'ADAM-10 joue un rôle critique. L'invention concerne enfin des procédés de fabrication de chlorures de bis-aryl-éthersulfonyle, et à partir de là, de modulateurs de l'ADAM-10.

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