Human adam-10 inhibitors

Details Human adam-10 inhibitors Human adam-10 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07C 309/87 (2006.01) C07D 213/70 (2006.01) C07D 241/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2485346

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.

La présente invention porte sur des composés utiles dans l'inhibition de la protéine ADAM-10, sélectivement par opposition à MMP-1. Ces composés sont utiles dans l'étude in vitro du rôle d'ADAM-10 (et son inhibition) dans des processus biologiques. La présente invention porte également sur des compositions pharmaceutiques comprenant un ou plusieurs inhibiteurs d'ADAM-10 de l'invention en combinaison avec un excipient acceptable d'un point de vue pharmaceutique. Ces compositions sont utiles dans le traitement du cancer, de l'arthrite et des maladies liées à l'angiogenèse. L'invention porte également sur des procédés de traitement de certaines formes de cancer, d'arthrite et de maladies liées à l'angiogenèse dans lesquelles ADAM-10 joue un rôle critique.

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