Human analogs of murine deubiquitinating protease genes

Details Human analogs of murine deubiquitinating protease genes Human analogs of murine deubiquitinating protease genes

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 45/00 (2006.01) C12N 9/16 (2006.01) C12N 9/50 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2476770

The present invention is directed to human analogs of murine hematopoetic- specific, cytokine-inducible deubiquinating proteases ("DUBs") clustered on chromosomes 4 and 8 and their respective regulatory regions. The nucleotides or proteins encoded thereby my be used in assays to identify inhibitors of human DUBs.

L'invention concerne des analogues humains de protéases murines de libération de l'ubiquitine ("DUB"), inductibles par cytokine et spécifiques du système hématopoïétique, groupés sur les chromosomes 4 et 8 et leurs régions régulatrices respectives. Les nucléotides ou les protéines codées ainsi peuvent être utilisés dans des tests d'identification d'inhibiteurs des DUB humaines.

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