C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01)
Patent
CA 2746778
Provided are human alpha-synuclein-spe-cific autoantibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for .alpha.--synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for .alpha.-synuclein targeted immunotherapy and diagnosis, respectively.
La présente invention concerne des auto-anticorps spécifiques de l'alpha-synucléine humaine ainsi que des fragments, des dérivés et des variantes desdits auto-anticorps et des méthodes apparentées. La présente invention concerne également des dosages, des kits et des supports solides correspondant aux anticorps spécifiques de la a-synucléine. L'anticorps, la ou les chaînes immunoglobulines, ainsi que des fragments de liaison, des dérivés et des variantes desdits éléments peuvent être employés dans des compositions pharmaceutiques et diagnostiques destinées respectivement à l'immunothérapie et au diagnostic ciblant la a-synucléine.
Grimm Jan
Hock Christoph
Nitsch Roger
Weihofen Andreas
Gowling Lafleur Henderson Llp
Panima Pharmaceuticals Ag
University Of Zurich
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