C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 37/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2614972
This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPl antibodies. Methods of detecting the amount of B7RP1 in a sample using anti- B7RPl antibodies are also provided.
L'invention concerne des anticorps qui interagissent avec la protéine 1 apparentée à B7 (B7RP1) ou qui se lient à celle-ci, ainsi que des anticorps qui se lient à B7RP1 ou qui en neutralisent la fonction. L'invention concerne également des compositions pharmaceutiques de ces anticorps et des méthodes destinées à neutraliser la fonction de B7RP1, notamment pour le traitement de troubles immunitaires (par ex., réponse immunitaire inappropriée), par administration d'une dose pharmaceutiquement efficace d'anticorps anti-B7RP1. L'invention se rapporte en outre à des méthodes destinées à détecter la concentration de B7RP1 dans un échantillon au moyen d'anticorps anti-B7RP1.
Huang Haichun
Shen Wenyan
Siu Gerald
Yoshinaga Steven Kiyoshi
Amgen Inc.
Gowling Lafleur Henderson Llp
Medarex Inc.
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