Human anti-cd40 antibodies

Details Human anti-cd40 antibodies Human anti-cd40 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2424296

Human antibodies capable of binding CD40 are disclosed, wherein the antibodies act as antagonists of CD40-directed activities of B cells, but have no or minimal ability to induce B cell proliferation. The antibodies are useful for treating diseases mediated by CD40-expressing cells, such as those diseases characterized by B cell activation, as well as cancer of B-cell lineage, including Non-Hodgkin's Lymphoma.

L'invention concerne des anticorps capables de se lier à CD40. Ces anticorps revêtent la fonction d'antagonistes des activités dirigées par CD40 des cellules B, mais leur capacité d'induire la prolifération des cellules B est nulle ou minimale. Lesdits anticorps sont utiles pour traiter des maladies induites par les cellules exprimant CD40, telles que les maladies caractérisées par l'activation des cellules B, ainsi que le cancer associé aux cellules B, y compris le lymphome non hodgkinien.

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