Human anti-epidermal growth factor receptor antibody

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2560305

The present invention provides a fully human antibody that binds human EGFR with affinity comparable to or higher than IMC-C225, and that neutralizes activation of EGFR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chains antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells and animals that encode and express these antibodies. The invention further provides a method for neutralizing activation of EGFR, treating in a mammal with neoplastic growth and non- cancerous hyperproliferative diseases using the antibodies alone or in combination with other agents.

L'invention concerne une bobine de condensateur destinée à un marchand de boissons réfrigérées et de restauration et comprenant une pluralité d'ailettes parallèles entre des tubes adjacents. Afin de réduire la probabilité d'encrassement par la liaison intermédiaire de fibres, l'écartement des ailettes est maintenu à une distance de 4 à 8 pouces. Dans un mode de réalisation, les tubes comportent des tubes microcanaux, sans ailettes intermédiaires, et l'écartement des tubes microcanaux est maintenu de l'ordre de 75 pouces pour optimiser les performances de transfert de chaleur tout en réduisant l'encrassement. En l'absence d'ailettes, une structure support est placée entre les tubes microcanaux. De plus, on dispose de plusieurs rangées de tubes microcanaux pourvues de têtes d'entrée séparées, les rangées étant transversalemente en quinconce pour améliorer les caractéristiques de transfet de chaleur tout en réduisant la probabilité d'encrassement.

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